stehlik-dorfleutner lab publications 2011-2015

Iyer AK, Azad N, Talbot S, Stehlik C, Lu B, Wang L, Rojanasakul Y. Antioxidant c-FLIP inhibits Fas ligand-induced NF-kappaB activation in a phosphatidylinositol 3-kinase/Akt-dependent manner. Journal of Immunology 2011, 187, p3256-3266. PMID:21856935  |   pdf

Stehlik, C. Macrophages, the Inflammasome and IL-1β in Cancer. The Journal of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, 2011, XIV, 44-52   |   pdf

Huang QQ, Koessler RE, Birkett R, Dorfleutner A, Perlman H, Haines GK 3rd, Stehlik C, Nicchitta CV, Pope RM. Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis. Arthritis and Rheumatology 2012, 64, p3638-3648. PMID:22777994   |   pdf

Shi B, Huang Q, Tak PP, Vervoordeldonk MJ, Huang CC, Dorfleutner A, Stehlik C, Pope RM. SNAPIN: an endogenous Tol-like receptor ligand in rheumatoid arthritis. Annals of the Rheumatic Disease 2012, 71, p1411-1417. PMID:22523426  |   pdf

Luanpitpong S, Chanvorachote P, Nimmannit U, Leonard SS, Stehlik C, Wang L, Rojanasakul Y. Mitochondrial peroxide mediates doxorubicin-induced keratinocyte apoptosis through oxidative modification of ERK and Bcl-2 ubiquitination. Biochemical Pharmacology 2012, 83, p1643-1654. PMID:22469513  |   pdf

Khare S, Dorfleutner A, Bryan NB, Yun C, Radian AD, de Almeida L, Rojanasakul Y, Stehlik C. An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages. Immunity 2012, 36, p464-476. PMID:22361007  |   pdf    |    Most-read article  |   Featured as a Research Highlight in Nature Reviews Immunology.Nature Reviews Immunology, 12, 358  |   pdf  |   Featured as a Research Highlight in Nature Immunology. Nature Immunology, 13, 358  |   pdf  |   press coverage: Northwestern University  |   pdf  |   The DailyNorthwestern  |   pdf  |   EurekAlert  |   pdf   |   LabSpaces  |   pdf  |   MediLexicon  |   pdf  |   Medical News Today  |   pdf  |   recommended by F1000Prime  |   pdf

Kung VL, Khare S, Stehlik C, Bacon EM, Hughes AJ, Hauser AR. An rhs gene of Pseudomonas aeruginosa encodes a virulence protein that activates the inflammasome. Proceedings of the National Academy of Sciences USA 2012, 109, p1275-1280. PMID:22232685  |   pdf   |   Featured as a Research Highlight in Nature. Nature, 481, 240 | pdf   |  Featured as a Research Highlight in Nature Immunology. Nature Immunology, 13 | pdf

Luanpitpong S, Chanvorachote P, Stehlik C, Tse W, Callery PS, Wang L, Rojanasakul Y. Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells. Molecular Biology of the Cell 2013, 24, p858-869. PMID:23363601  |   pdf

Ratsimandresy RA, Dorfleutner A*, Stehlik C*. An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology. Frontiers in Immunology 2013, 4, p440. PMID:24367371  |   pdf

Radian AD, de Almeida L, Dorfleutner A*, Stehlik C*. NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease. Microbes and Infection 2013, 15, p630-639. PMID:23618810  |  pdf

Cuda CM, Misharin AV, Gierut AK, Saber R, Haines GK 3rd, Hutcheson J, Hedrick SM, Mohan C, Budinger GS, Stehlik C, Perlman H. Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation. Journal of Immunology 2014 , 192, p5548-5560. PMID:24808358  |   pdf   |   featured “in this issue”  |   pdf

Talbott SJ, Luanpitpong S, Stehlik C, Azad N, Iyer AK, Wang L, Rojanasakul Y. S-nitrosylation of FLICE inhibitory protein determines its interaction with RIP1 and activation of NF-κB. Cell Cycle 2014, 13, p1948-1957. PMID:24762656  |   pdf

Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A*, Stehlik C*. The PYRIN domain-only rotein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nature Immunology 2014, 15, p343-353. PMID:24531343   |   pdf  |   highlighted with a News and Views Commentary by Krishnaswamy J.K., Liu D. and Eisenbarth S.C. (2014) POP goes the inflammasome. Nature Immunology, 15, 311-313   |   pdf   |   selected as the cover article   |   pdf   |   featured by the Austrian Presse Agentur (APA) and MedOnline   |   pdf   | (in Italian)   |   pdf   |   Nature Asia   |   pdf   |   Feinberg News   |   pdf

Cuda CM, Misharin AV, Khare S, Saber R, Tsai F, Archer AM, Homan PJ, Haines GK 3rd, Hutcheson J, Dorfleutner A, Budinger GR, Stehlik C, Perlman H. Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner. Arthritis Research and Therapy 2015, 17, p291. PMID:26471282  |   pdf 

de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy RA, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A*, Stehlik C*. The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease. Immunity 2015, 43, p264-276. PMID:26275995  |   pdf    |    Selected for display at the Immunity website  |   pdf  |   highlighted with a Commentary by Shimada K. Timothy R. Crother T.R., and Arditi, M. (2015) POPsicle for Fever! Cooling Down the Inflammasome. Immunity, 43, 213-215  |   pdf  |   press coverage: Northwestern University  |   pdf  |   the Rheumatologist  |   pdf

Dorfleutner A*, Chu L, Stehlik C*. Inhibiting the inflammasome: one domain at a time. Immunology Reviews 2015, 265, p205-216. PMID:25879295  |   pdf

Thorp EB, Stehlik C, Ansari MJ. T-cell exhaustion in allograft rejection and tolerance. Current Opinion in Organ Transplantation 2015, 20, p37-42. PMID:25563990  |   pdf

Chu LH, Gangopadhyay A, Dorfleutner A*, Stehlik C*. An updated view on the structure and function of PYRIN domains. Apoptosis 2015, 20, p157-173. PMID:25451010   |   pdf

Radian AD, Khare S, Chu LH, Dorfleutner A*, Stehlik C*. ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides. Molecular Immunology 2015, 67, p294-302. PMID:26143398   |  pdf

Queen J, Agarwal S, Dolores JS, Stehlik C, Satchell KJ. Mechanisms of inflammasome activation by Vibrio cholerae secreted toxins vary with strain biotype. Infection and Immunity 2015, 83, p2496-2506. PMID:25847959  | pdf