maintenance of intestinal homeostasis
Tolerance toward commensal bacteria is key for promoting microbial diversity, maintaining intestinal homeostasis, preventing pathogen infection and systemic disease by shaping immune responses also outside of the intestine. Our ongoing studies aim to elucidate the molecular mechanisms involved in the maintenance of this tolerance and investigate events that lead to a break in tolerance for instance as in inflammatory bowel disease, colorectal cancer and other diseases.
 Ratsimandresy RA, Indramohan M, Dorfleutner A*, Stehlik C*. The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. Cellular and Molecular Immunology 2017, 14, p127-142. PMID:27524110 | pdf